What is the most likely anesthetic implication of chronic phenobarbital use?

What is the most likely anesthetic implication of chronic phenobarbital use?

• A. Etomidate is contraindicated
• B. Propofol is contraindicated
• C. Slower metabolism of hepatically metabolized drugs
• D. Rapid metabolism of hepatically metabolized drugs

Answer: (C)

Chronic use of phenobarbital, a barbiturate used primarily for seizure control, has significant implications for anesthetic management, particularly regarding drug metabolism. Chronic exposure to phenobarbital induces liver enzymes, specifically the cytochrome P450 system. This enzyme induction increases the metabolic capacity of the liver, leading to enhanced clearance of various drugs that are metabolized hepatically. The correct answer highlights the slower metabolism of hepatically metabolized drugs, which is linked to the effects of phenobarbital. However, in reality, patients on chronic phenobarbital often demonstrate an increased rate of metabolism for other drugs due to enzyme induction. Hence, it's essential for anesthesiologists to adjust dosages of drugs that are uniquely dependent on hepatic metabolism in these patients. In summary, chronic phenobarbital use leads to alterations in drug metabolism by enhancing the liver's ability to metabolize certain anesthetics and other medications, necessitating careful consideration in anesthetic planning.

Chronic use of phenobarbital, a barbiturate used primarily for seizure control, has significant implications for anesthetic management, particularly regarding drug metabolism. Chronic exposure to phenobarbital induces liver enzymes, specifically the cytochrome P450 system. This enzyme induction increases the metabolic capacity of the liver, leading to enhanced clearance of various drugs that are metabolized hepatically.

The correct answer highlights the slower metabolism of hepatically metabolized drugs, which is linked to the effects of phenobarbital. However, in reality, patients on chronic phenobarbital often demonstrate an increased rate of metabolism for other drugs due to enzyme induction. Hence, it's essential for anesthesiologists to adjust dosages of drugs that are uniquely dependent on hepatic metabolism in these patients.

In summary, chronic phenobarbital use leads to alterations in drug metabolism by enhancing the liver's ability to metabolize certain anesthetics and other medications, necessitating careful consideration in anesthetic planning.