In the parturient, what is the approximate elimination half-life of intravenously administered oxytocin?

In the parturient, what is the approximate elimination half-life of intravenously administered oxytocin?

• A. 30 to 120 seconds
• B. 10 to 15 minutes
• C. 20 to 30 minutes
• D. 3 to 5 minutes

Answer: (D)

The elimination half-life of intravenously administered oxytocin in parturients is approximately 3 to 5 minutes. This rapid half-life is significant as it allows for quick adjustments in dosage based on the patient's response to the medication, which is important during labor. Oxytocin is primarily used to augment labor contractions and can be rapidly removed from circulation, enabling effective management of uterine tone and contraction frequency. This short half-life is primarily due to its metabolism by the liver and kidneys, which occurs shortly after administration. Understanding this pharmacokinetic profile is essential for healthcare providers when managing labor and delivery, as it helps in making informed decisions regarding the timing and dosing of oxytocin to optimize maternal and fetal outcomes.

The elimination half-life of intravenously administered oxytocin in parturients is approximately 3 to 5 minutes. This rapid half-life is significant as it allows for quick adjustments in dosage based on the patient's response to the medication, which is important during labor. Oxytocin is primarily used to augment labor contractions and can be rapidly removed from circulation, enabling effective management of uterine tone and contraction frequency.

This short half-life is primarily due to its metabolism by the liver and kidneys, which occurs shortly after administration. Understanding this pharmacokinetic profile is essential for healthcare providers when managing labor and delivery, as it helps in making informed decisions regarding the timing and dosing of oxytocin to optimize maternal and fetal outcomes.